Local allergic rhinitis (LAR) is a clinical entity characterized by a localized allergic response in the nasal mucosa in the absence of evidence of systemic atopy [9,10,11]. By definition, patients with LAR have negative skin tests and/or in vitro tests for IgE, but have evidence of local IgE production in the nasal mucosa; these patients also react to nasal challenges with specific allergens [12].
Planning on buying an S5 Have a nose at these
The symptoms of LAR are similar to those provoked in patients with allergic rhinitis, and the assumption is that LAR is an IgE-mediated disease based on both clinical findings and the detection of specific IgE in the nasal mucosa. To date, there is no evidence to suggest that LAR is a precursor to allergic rhinitis since follow-up does not show the evolution to typical allergic rhinitis in these patients [13]; however, patient follow-up may not have been long enough to detect this disease evolution. The implications for treatment of LAR are not well understood at this time, although some evidence suggests that allergen immunotherapy may be effective in this type of rhinitis [9, 11].
It is important to note that most patients with allergic rhinitis presenting to their primary-care physician have moderate-to-severe symptoms and will require an intranasal corticosteroid. Bousquet et al. [30] noted improved outcomes in patients with moderate-to-severe symptoms treated with a combination of these agents.
These are grand touring cars designed to cover lots of ground at high speed while coddling a pair of occupants. They seat two-plus-two; the rear seats are for the occasional adult passengers or for bringing small kids along. The A5 involves the driver physically, audibly, and mentally though never to the point of making it a chore or less than inviting. The Audi S5 can be hustled down virtually any road at a good clip, but it is unfair to expect these coupes to behave like small sports cars. Audi interiors have been racking up awards for a long time and the A5 (and S5) is in the same mold. It has the features expected, good ergonomics, a central interface system that won't drive you to cursing, and it's all assembled to a high standard using appropriate materials. Despite the standard all-wheel drive it also has more trunk space than some Lexus sedans, so you can enjoy a road trip of just about any length or destination. An A5 delivers confidence and luxury in a package not likely to be seen at every intersection and very likely to come across as a good value; the S5 delivers more performance and luxury yet still has a certain value quotient to argue. By price, concept, and execution one of the S5's nearest competitors is the Mercedes-Benz CLK550, with a bit more power but no choice of transmission, no all-wheel drive, and costing about $5,000 more. While the $40,700 A5 and $51,400 S5 may be judged on paper against the Infiniti G37, CLK350, or BMW 335i coupe, the amenities, cabin finish and room are such that the Audis may also be shopped against the Jaguar XK, BMW 650i, or Porsche 911. And while each is a fine car and may offer more speed or perhaps technological gadgetry, only the 911 matches the Audi with the availability of all-wheel drive, and for a $6,000 premium. The A5 and S5 were launched as 2008 models and have been on the market for only a short time, so there are no significant changes for 2009. Full ReviewThe Audi A5 and the high-performance S5 are mid-size coupes, larger than the TT. A handsome, distinctive shape identifies the A5 and S5 models from virtually any angle, with flowing curves bringing musculature to sleek, aerodynamic forms and arresting light patterns. Viewed from behind there's a chance of mistaking an A5 or S5 for a British GT, but from any other angle it's unmistakably Audi. These are grand touring cars designed to cover lots of ground at high speed while coddling a pair of occupants. They seat two-plus-two; the rear seats are for the occasional adult passengers or for bringing small kids along. The A5 involves the driver physically, audibly, and mentally though never to the point of making it a chore or less than inviting. The Audi S5 can be hustled down virtually any road at a good clip, but it is unfair to expect these coupes to behave like small sports cars. Audi interiors have been racking up awards for a long time and the A5 (and S5) is in the same mold. It has the features expected, good ergonomics, a central interface system that won't drive you to cursing, and it's all assembled to a high standard using appropriate materials. Despite the standard all-wheel drive it also has more trunk space than some Lexus sedans, so you can enjoy a road trip of just about any length or destination. An A5 delivers confidence and luxury in a package not likely to be seen at every intersection and very likely to come across as a good value; the S5 delivers more performance and luxury yet still has a certain value quotient to argue. By price, concept, and execution one of the S5's nearest competitors is the Mercedes-Benz CLK550, with a bit more power but no choice of transmission, no all-wheel drive, and costing about $5,000 more. While the $40,700 A5 and $51,400 S5 may be judged on paper against the Infiniti G37, CLK350, or BMW 335i coupe, the amenities, cabin finish and room are such that the Audis may also be shopped against the Jaguar XK, BMW 650i, or Porsche 911. And while each is a fine car and may offer more speed or perhaps technological gadgetry, only the 911 matches the Audi with the availability of all-wheel drive, and for a $6,000 premium. The A5 and S5 were launched as 2008 models and have been on the market for only a short time, so there are no significant changes for 2009. Hide Full ReviewChoose a Trim2dr All-wheel Drive quattro Coupe (4.2L)Retail Price$51,400 - $51,400MSRP / Window Sticker PriceFind Best PriceEngine4.2L V-8MPGUp to 14 city / 22 highwaySeating4 PassengersTransmission6-spd man w/ODPower354 @ 6800 rpmDrivetrainquattro all wheelCurb Weight3,891 lbsSmart Buy Program is powered by Latest S5 NewsAudi launches subscription service: Here's what $1,395 a month gets you
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Research Another Vehicle2009 Audi S5 trims (1)Trim Family4.2LYears2023202220212020201920182017201620152014201320122011201020092008(4.2L) 2dr All-wheel Drive quattro CoupeMSRP$51,400Engine4.2L V-8MPG14 city / 22 hwyExploreBuild & PricePopular VehiclesPopular New Vehicles2023 Toyota Tacoma
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